Endocrinology: 3-Volume Set

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		Endocrinology: 3-Volume Set
		Endocrinology: 3-Volume Set

基本信息·出版社：Saunders
·页码：4144 页
·出版日期：2005年08月
·ISBN：0721603769
·International Standard Book Number：0721603769
·条形码：9780721603766
·EAN：9780721603766
·版本：5
·装帧：精装
·正文语种：英语
·丛书名：Endocrinology (DeGroot)
·套装数量：3

内容简介 Revised throughout, the 5th Edition of this leading reference presents a complete and up-to-date review and analysis of all aspects of endocrinology, diabetes, and bone metabolism. Readers will also find state-of-the-art information on genetics, proteinomics, and hormone signaling, and coverage of the field?s hottest topics in nearly 20 new chapters. Joined by an international team of leading experts?many new to this edition?Drs. Jameson and DeGroot provide guidance that integrates the basic science of endocrinology with clinical medicine and the practical management of endocrine disorders. A clinical focus emphasizes diagnosis and therapy.* Features the work of the world?s leading authorities?many new to this edition. * Organizes information into basic and clinical sections that makes reference quick and easy. * Provides tables designed to summarize and organize information, and presents over 1,400 illustrations that clarify complex concepts.
作者简介 Leslie J. DeGroot, MD, Professor of Medicine and Radiology and Committee on Immunology, University of Chicago School of Medicine, Chicago, IL; and J. Larry Jameson, MD, PhD, Irving S. Cutter Professor of Medicine and Chairman, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL
目录
I. PRINCIPLES OF HORMONE ACTION

1. Endocrinology: Impact on science and medicine


II. GENOMICS & ENDOCRINOLOGY

2.Hormones and gene expression: basic principles
3.Cell division, differentiation, senescence, and death
4.Appication of genomics and proteinomics to endocrinology
5.Transgenic and genetic animal models
6.Genetic syndromes in endocrinology


III.MECHANISMS OF ENDOCRINE SIGNALING & RESPONSE

7.Control of hormone secretion
8.Hormone signaling via tyrosine kinase receptors
9.Hormone signaling via cytokine receptors
10.Hormone signaling via serine kinase receptors
11.Hormone signaling via G-protein coupled receptors
12.Cyclic AMP signaling pathway
13.Second messenger signaling pathways: Phospholipids and calcium
14.MAP kinase and growth factor signaling pathways
15.Nuclear receptors: Sturcture, function and co-factors


IV. NEUROENDOCRINOLOGY & PITUITARY DISEASE

16.Development of the pituitary
17.Prolactin
18.ACTH
19.Endocrine rhythms and the clock
20.Hypothalamic syndromes
21.Evaluation of hypothalamic and pituitary masses
22.Hypopituitarism
23.Acromegaly
24.Cushing's Disease and Syndrome
25.Non-functioning ademonas and gonadotrophinomas
26.TSH-producing adenomas
27.Prolactinoma
28.Pituitary surgery
29.Evaluation and management of childhood hypothalamic and pituitary tumors
30.Posterior pituitary, diabetes insipidus, SIADH
31.The pineal gland: basic physiology and clinical implications


V. GROWTH & MATURATION

32.Growth hormone
33.Regulation of GH secretion
34.ICH-I, IGF-BPs, and IFG-II
35.Other growth factors
36.Growth and maturation
37.Growth hormone deficiency in children
38.Growth hormone deficiency in adults


VI. IMMUNOLOGY & ENDOCRINOLOGY

39.Autoimmune endocrine disease
40.Interactions of the Endocrine and Immune Systems
41.Autoimmune polyglandular failure syndromes


VII.OBESITY, ANOREXIA, AND NUTRITION

42.Appetite regulation and thermogenesis
43.Obesity: The problem and its management
44.Genetics and syndromes of obesity (
45.Anorexia Nervosa, Bulimia Nervosa, and other eating disorders
46.Starvation and parenteral


VIII.DIABETES MELLITUS

47.Development of the endocrine pancreas
48.Chemistry and biosynthesis of the islet hormones
49.Secretion and metabolism of insulin
50.Insulin action
51.Glucagon and the glucagon-like peptides
52.Integrated control of energy substrate utilization
53.Role of the adipocyte in metabolism and endocrine function
54.Classification and diagnosis of diabetes mellitus
55.Type 1 (Insulin-dependent) diabetes mellitus: Etiology, pathogenesis, and natural history
56.Type 2 diabetes mellitus: Etiology, pathogenesis, and natural history
57.Hyperglycemia secondary to non-diabetic conditions and therapies
58.Syndromes of insulin resistance and lipodystrophy
59.Metabolic syndrome
60.Treatment of Type 1 diabetes mellitus in adults
61.Ketoacidosis and hyperosmolar coma
62.Hypoglycemia
63.Management of Type 2 diabetes mellitus
64.Management of diabetes in children
65.Pancreatic and islet transplantation
66.Relationship of diabetic control to complications
67.Diabetic oculopathy
68.Diabetic neuropathy
69.Diabetic nephropathy
70.Diabetic foot and vascular complications


IX.PARATHYROID GLAND, CALCIOTROPIC HORMONES & BONE METABOLISM

71.Parathyroid hormone and parathyroid hormone-related peptide
72.Calcitonin
73.Vitamin D
74.Regulation of calcium homeostasis
75.Bone development and remodeling
76.Genetic defects in the parathyroid axis
77.Hyperparathyroidism: Differential diagnosis of
78.Malignancy-associated hypercalcemia
79.Medical treatment of hypercalcemia
80.Surgical management of hypercalcemia
81.Familial hypocalciuric hypercalcemia and other disorders due to calcium-sensing receptor mutations
82.Hypoparathyroidism and pseudohypoparathyroidism
83.Genetic defects in vitamin D metabolism and action
84.Nephrolithiasis
85.Genetic Defects and Disorders of Bone
86.Bone imaging and assessment of bone density
87.Renal osteodystrophy
88.Osteomalacia and rickets
89.Osteoporosis
90.Paget's Disease of bone

X.THYROID

91.Development of the
92.Thyroid-stimulating hormone and regulation of the thyroid
93.Thyroid hormone formation
94.Thyroid Regulatory
95.Thyroid hormone metabolism
96.Thyroid hormone action
97.Throid function tests: Effects of drugs and disease on the thyroid
98.Thyroid
99.Autoimmune thyroid disease
100.Graves' Disease
101.Graves' Ophthalmopathy
102.Other causes of hyperthyroidism
103.Chronic (Hashimoto's) thyroiditis
104.Subacute and Reidel's thyroiditis
105.Hypothyroidism and myxedema coma
106.Nonthyroidal illness syndrome
107.Multinodular goiter
108.Iodine defieciency
109.Thyroid nodules and Thyroid
110.Medullary thyroid carcinoma
111.TSH receptor mutations
112.Genetic Defects in Thyroid Hormone Synthesis and Action: Defects in Thyroid Hormone
113.Thyroid Hormone Binding and Variants of Transport Proteins
114.Resistance to thyroid hormone
115.Surgery of the thyroid: Abberant thyroid masses


XI.ADRENAL GLAND AND ADRENAL HORMONES

116.The principles, pathways, and enzymes of human steroidogenesis
117.Glucocorticoid physiology
118.Gulcocorticoid receptors and their mechanisms of action
119.Aldosterone: Secretion and
120.Glucocorticoid therapy
121.Adrenal insufficiency/Cushing's Disease
122.Adrenal causes of hypercortisolism
123.Generalized Glucocorticoid resistance
124.Congenital adrenal
125.Adrenarche and adrenopause
126.Adrenal imaging and adrenal incidentaloma
127.Adrenal neoplasia
128.Primary mineralocorticoid excess
129.Mineralocorticoid deficiency
130.Pheochromocytoma
131.Adrenal surgery


XII.CARDIOVASCULAR ENDOCRINOLOGY

132.Hormones of the cardiovascular system
133.Hormonal regulation of electrolyte and water metabolism
134.Endocrine changes in CHF
135.Management of lipid disorders
136.Essential hypertension and endorine hypertension
137.Orthostatic hypotension


XIII.ENDOCRINE CHANGES IN CRITICALLY ILL PATIENTS

138.Endocrine aspects of critical care


XIV.REPRODUCTIVE ENDOCRINOLOGY AND SEXUAL FUNCTION

139.GnRH and gonadotropins
140.Gonadal peptides: Inhibins, activins, follistatin, MIS
141.Regulation of gonadotropin synthesis and secretion
142.Genetic basis of sexual differentiation
143.Embryology and control of sex differentiation
144.Endocrinology of sexual maturation
145.Environmental agents and the reproductive system
146.Diagnosis and treatment of disorders of sexual development
147.Precocious puberty
148.Delayed puberty
149.Gender identity and sexual behavior


XV.FEMALE REPRODUCTION

150.Folliculogenesis, ovulation, and luteogenesis
151.Ovarian hormone synthesis and secretion
152.Estrogen and progesterone action
153.Hormonal regulation of the menstrual cycle and mechanisms of ovulation
154.Amenorrhea, anovulation, and dysfunctional uterine bleeding
155.Endometriosis
156.Female infertility: Evaluation and management
157.Polycystic ovarian syndrome, hirsutism, and hyperandrogenism
158.Ovulation induction and assisted reproduction
159.Contraception
160.Female sexual dysfunction
161.Premenstual syndrome
162.Mechanisms of menopause and the menopausal transition
163.Ovarian tumors with endocrine manifestations


XVI.ENDOCRINOLOGY OF THE BREAST

164.Hormonal control of the breast development
165.Benign breast disorders
166.Breast cancer and hormonal mangement


XVII. MALE REPRODUCTION

167.Spermatogenesis and regulation of testicular function
168.Androgens and androgen action
169.Androgen receptors and androgen insensitivity syndromes
170.Androgen deficiency disorders
171.Cryptorchidism and hypospadias
172.Male infertility
173.Male sexual dysfunction
174.Male contraception
175.Testicular tumors with Endocrine Manifestations
176.Use and abuse of anabolic steroids
177.Gynecomastia
178.Physiology and pathophysiology of androgenetic alopecia
179.Endocrinology of the Prostate and Benign Prostatic Hyperplasia
180.Prostate cancer


XVIII. ENDOCRINOLOGY OF PREGNANCY

181.Implantation and placental physiology
182.Placental hormones
183.Fetal and neonatal endocrinology
184.Fuel homeostasis in the fetus and neonate
185.Endocrinology of partuition
186.Diabetes mellitus and pregnancy
187.Diagnosis and treatment of thyroid disease during pregnancy
188.Lactation
189.Gestational trophoblastic neoplasms
190.Hormonal changes and endocrine testing in pregnancy


XIX. ENDOCRINE TUMOR SYNDROMES

191.Multiple endocrine neoplasia Type 1
192.Multiple endocrine neoplasia Types IIa and IIb
193.Gastrointestinal hormones and tumor syndromes
194.Carcinoid syndrome
195.Ectopic hormone syndromes


XX. ENDOCRINE TESTING AND ENDOCRINE DRUG

196.Endocrine testing
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