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Ending Aging: The Rejuvenation Breakthroughs That Could Reverse Human Aging in Our Lifetime |  |
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Ending Aging: The Rejuvenation Breakthroughs That Could Reverse Human Aging in Our Lifetime | |
MUST WE AGE?
A long life in a healthy, vigorous, youthful body has always been one of humanity's greatest dreams. Recent progress in genetic manipulations and calorie-restricted diets in laboratory animals hold forth the promise that someday science will enable us to exert total control over our own biological aging.
Nearly all scientists who study the biology of aging agree that we will someday be able to substantially slow down the aging process, extending our productive, youthful lives. Dr. Aubrey de Grey is perhaps the most bullish of all such researchers. As has been reported in media outlets ranging from 60 Minutes to The New York Times, Dr. de Grey believes that the key biomedical technology required to eliminate aging-derived debilitation and death entirely—technology that would not only slow but periodically reverse age-related physiological decay, leaving us biologically young into an indefinite future—is now within reach.
In Ending Aging, Dr. de Grey and his research assistant Michael Rae describe the details of this biotechnology. They explain that the aging of the human body, just like the aging of man-made machines, results from an accumulation of various types of damage. As with man-made machines, this damage can periodically be repaired, leading to indefinite extension of the machine's fully functional lifetime, just as is routinely done with classic cars. We already know what types of damage accumulate in the human body, and we are moving rapidly toward the comprehensive development of technologies to remove that damage. By demystifying aging and its postponement for the nonspecialist reader, de Grey and Rae systematically dismantle the fatalist presumption that aging will forever defeat the efforts of medical science.
网友对Ending Aging: The Rejuvenation Breakthroughs That Could Reverse Human Aging in Our Lifetime的评论
Aubrey de Grey is a rare combination of head in the stratosphere, feet on the ground unique thinker.
The world is filled with people who have grandiose thoughts but a complete unwillingness to do the leg work to check on the research that would make their thoughts scientific method test of, "Does it fit the data." And it is filled with people who cherry pick only the data that fits their theory. The world also has ample share of people who treat data as if there is no bigger picture, that the only valid ideas are those that are right there at ground level.
Ending Aging doesn't take either of those 3 well-worn paths. Ending Aging takes in all the data, points out the limitations of it's own theories, builds a framework of thinking in which one can plan out a research strategy that isn't about aging gracefully, isn't about more life in our years, but is really about taking a comprehensive approach to putting aging in the same dustbin of history that we've already placed tetanus, polio, small pox and dozens of other past scourges of humanity.
Ending aging is both bold and realistic, both broad brush strokes and deep dive. Ending aging isn't light reading. It's not a plan to follow some past paleo, natural guru whiz-bang notion. It is instead a credible, well thought out plan to attack aging at it's most vulnerable point, the addressable end products of the aging process.
"Ant-Aging: has been aproached scientifically before. "Ending Aging" is the first book to apply engineering perspectives and disciplines to the process of aging. Engineering isn't done by mastering every trait, but by bounding problems within a tolerance level where predictability is possible. It is this new concept that makes ending aging a breakthrough watershed book in the field.
A very important book.
Basically, explains:
1. All age-related health conditions (cancer, alzheimer's, heart disease)
are actually only caused by the component cells deteriorating
2. There are 7 ways that our cells deteriorate
A. how this happens
B. how we need to deal with each of the 7 ways
3. We can research how to maintain our cells, like we maintain a car,
4. Refutes the arguments against ending aging (eg population, etc)
Through this book, de Grey and Rae introduced some very novel ideas that seem to slowly be getting some traction.
The idea is that unwanted aging is best prevented by identifying and removing cumulative damage, and not trying to figure out exactly which biological mechanisms and processes cause it. Though that might be preferable, it's probably not as attainable.
In essence, cure the disease, not the cause(s) or the symptom(s). Many feel the book devalues the approach of gerontologists. Maybe I'm wrong, but for me it doesn't. It only highlights the fact that gerontology isn't intent on preventing unwanted biological aging in humans. As such, it isn't as pragmatic, effective or realistic an approach to solving that problem. Being interested in aging, and wanting to prevent some aspect of it are, or can be two very different things. And that's fine.
In some sense, the book argues that many conditions that are seen as age-related diseases, are just symptomatic of the larger disease of aging. They're subsets of aging. This seems fairly logical, but I'm not sure to what extent it's accurate. For one thing, it can be hard to differentiate between age- and time-dependent disease. In any case, it definitely has merit as an idea.
The writing style is good, but very conversational. Some further editing might help. This isn't necessarily a bad thing, as it might make the book approachable to a wider audience. So I don't think it suffers too much from that, but I personally would like more clarity and brevity. I would also like some more detail, but that's what the internet is for.
Basically this is a very good introduction for someone who isn't familiar with regenerative medicine. With all the interviews, etc it might feel as if Aubrey de Grey is just echoing himself, but consider his target audience. It's important to keep the message fairly simple, fairly consistent and fairly current. He does that in shovels.
I am an avid supporter of anti-aging research and rejuvenation technologies. I wanted to read Aubrey De Grey's book because it seemed to be a great way to get a broad idea of what kinds of research people are doing, and what needs to be done in order to keep us youthful and healthy forever. I like the approach he takes, detailing his thought process in the beginning of the book and at the beginning of each chapter or section, and then explaining the scientific details in a way that a learned non-scientist could understand it. I know little to nothing about mitochondriopathy, for example, but I was able to understand what he was explaining in the book to some degree. Though the book may be over some people's heads (mine including), it's a great way to learn more about the research if you know about science, or if you yourself are a scientist looking to expand on the field. I'd recommend this book to any biologist, biochemical researcher, or anyone in a similar field looking for ways to expand their research in a meaningful way.
Frankly, if we gave more attention to anti-aging research, we'd be able to move this along quickly and also cure numerous diseases in the process, as well as prevent many others.
I'm almost done with the book. :)
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