Probes and Tags to Study Biomolecular Function: for Proteins, RNA, and Membranes
基本信息·出版社：Wiley VCH ·页码：193 页 ·出版日期：2008年09月 ·ISBN：3527315667 ·条形码：9783527315666 ·装帧：精装 ·正文语种：英语 ·外 ...
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Probes and Tags to Study Biomolecular Function: for Proteins, RNA, and Membranes |
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基本信息·出版社：Wiley VCH
·页码：193 页
·出版日期：2008年09月
·ISBN：3527315667
·条形码：9783527315666
·装帧：精装
·正文语种：英语
·外文书名：研究生物分子功能的探针与标签: 用于蛋白质,核糖核酸与膜
内容简介 在线阅读本书
The only resource to systematically review current experimental methods, this handy reference enables researchers to select the best solution for their experimental problems. For each method covered, the book provides step–by–step protocols, illustrated by typical research applications. After an initial section on probing the lipid bilayer, the text moves on to discuss probing proteins –– including membrane proteins –– and nucleic acids. The first single publication to incorporate chemical markers, fluorescent probes and genetic tags allows a well–informed comparison of different solutions for the same problem in molecular analytics.
作者简介 Lawrence Miller is Assistant Professor of Chemistry at the University of Illinois at Chicago. He obtained both his B.S. and Ph.D. from the University of Wisconsin–Madison. He then moved to Columbia University in the City of New York to initiate an independent research project specialising in novel imaging technology for the biosciences. His research interests include chemical methods to advance molecular imaging, in vivo study of biochemical and biomolecular function and bioanalytical chemistry. He has 3 patents and several papers to his name.
媒体推荐 "The book is a welcome addition to the literature that will be valued by a broad range of researchers in cell biology and biochemistry." (
Doody's, May 2009)
"The quality of the book is good and its importance to the chemical community is high. I congratulate the editor on his first book. I am sure I will return to this book many times in the future." (Journal of the American Chemical Society, February 4, 2009)
专业书评 In order to study living cells and their component molecules, two basic strategies have emerged in recent years. The first is to apply a soluble marker molecule, a 'probe', that partitions to a particular cellular domain, and which can subsequently be measured. The second is to chemically or genetically modify a molecule of interest with a built-in probe, which is then called a 'tag'.
This handy reference systematically reviews current experimental methods and enables researchers to select the best solution for their experimental problems. For each method covered, the book provides step-by-step protocols, illustrated by typical research applications. Commencing with probing the lipid bilayer, the text then moves on to discuss probing proteins -- including membrane proteins -- and nucleic acids. This is the first single publication to incorporate chemical markers, fluorescent probes and genetic tags to allow a well-informed comparison of different solutions for similar problems in molecular analytics.
